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Vermillion is a cozy community of 10,000 and home to the University of South Dakota Coyotes. Vermillion offers an excellent place to live, learn, work, and raise a family. The Vermillion School district is among the top 100 in America. Vermillion is located 10 miles west of Interstate 29, 55 miles from Sioux Falls, SD and 130 miles from Omaha, NE.